Last edited by Akisho
Wednesday, July 22, 2020 | History

2 edition of treatment of human trypanosomiasis with tryparsamide found in the catalog.

treatment of human trypanosomiasis with tryparsamide

Louise Pearce

treatment of human trypanosomiasis with tryparsamide

a critical review

by Louise Pearce

  • 218 Want to read
  • 24 Currently reading

Published by The Rockefeller Institute for Medical Research in New York .
Written in English

    Subjects:
  • Trypanosomiasis.,
  • Tryparsamide.

  • Edition Notes

    Includes bibliographical references (p. 229-230).

    Statementby Louise Pearce.
    SeriesMonographs of the Rockefeller Institute for Medical Research ;, no. 23
    Classifications
    LC ClassificationsR108 .R65 no. 23
    The Physical Object
    Pagination339 p. ;
    Number of Pages339
    ID Numbers
    Open LibraryOL6750256M
    LC Control Number30030030
    OCLC/WorldCa3176269

    Lakshmi P. Kotra, in xPharm: The Comprehensive Pharmacology Reference, Introduction. American Trypanosomiasis (Chagas' Disease) and African Trypanosomiasis (Sleeping Sickness) are the two most common human illnesses caused by trypanosome ' disease is a zoonosis caused by the parasite Trypanosoma ' disease is a mild febrile illness in the acute phase, . African trypanosomiasis, also known as African sleeping sickness or simply sleeping sickness, is an insect-borne parasitic infection of humans and other animals. It is caused by the species Trypanosoma brucei. Humans are infected by two types, Trypanosoma brucei gambiense (TbG) and Trypanosoma brucei rhodesiense (TbR). TbG causes over 98% of reported : Trypanosoma brucei spread by tsetse flies.

      Title page of Pearce's The Treatment of Human Trypanosomiasis with Tryparsamide Tryparsimide was derived from arsenic. In Paul Ehrlich, in Germany, had developed an arsenic-derived drug called Salvarsan, which was the first effective treatment for syphilis. Treatment of second-stage gambiense human African trypanosomiasis relied on toxic arsenic-based derivatives for over 50 years. The a vailability and subsequent use of eflornithine, initially in monotherapy and more recently in combi nation with nifurtimox (NECT), has .

      Tryparsamide, applied to the treatment of trypanosomiasis in man by Pearce, 2 also showed a tendency to produce visual disturbances. In her series of seventy-seven patients with trypanosomiasis, nine developed visual impairment. In three ofCited by: STUDIES ON THE TREATMENT OF HUMAN TRYPANOSOMIASIS WITH TRYPARSAMIDE (THE SODIUM SALT OF N-PHENYLGLYCINEAMIDE-p-ARSONIC ACID). Pearce L. J Exp Med, 34(6 suppl 1), 01 Nov Cited by: 1 article | PMID: | PMCID: PMC Free to read & use.


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Treatment of human trypanosomiasis with tryparsamide by Louise Pearce Download PDF EPUB FB2

Treatment of Human Trypanosomiasis by Tryparsamide. Foreign Title: Traitement de la trypanosomiase humaine par la tryparsamide. Author(s): Laigret, : J.

Laigret. It has been shown that tryparsamide, the sodium salt of N-phenylglycineamide-p-arsonic acid, possesses a marked trypanocidal activity in human trypanosomiasis caused by Tr.

gambiense. Single doses of from to gm. produced a peripheral sterilization of lymph glands Cited by: The treatment of human trypanosomiasis with tryparsamide: a critical review.

[Louise Pearce] Treatment of human trypanosomiasis with tryparsamide. New York: Rockefeller Institute for Medical Research, (OCoLC) # The treatment of human trypanosomiasis with tryparsamide: a critical review\/span>\n \u00A0\u00A0\u00A0\n. Treatment of Human Trypanosomiasis by Atoxyl, Tryparsamide and Fourneau Foreign Title: Traitement de la trypanosomiase humaine par l'atoxyl, la tryparsamide et le Fourneau.

Résultats acquis en Afrique Équatoriale : Vaucel. This is a preface introducing the following eight papers on the use of tryparsamide in human tripanosomiasis Tryparsamide is the sodium salt of N-phenyigrycinamide-p-arsenic acid It is a white crystalline powder, odourless, readily soluble in water and stable under ordinary conditions The dose for an adult is 2 to 3 gm, and for a child 5 to 1 gm according to its age The author favours weekly Author: F.

Van Den Branden. Information is given regarding the treatment of twenty cases of sleeping sickness with tryparsamide. In most of the cases the doses given were insufficient. Employment of Tryparsamide in the Treatment of Human Trypanosomiasis. Preface.

African trypanosomiasis african trypanosomiasis Subject Category: Diseases, Disorders, and SymptomsAuthor: David. STUDIES ON THE TREATMENT OF HUMAN TRYPANOSOMIASIS WITH TRYPARSAMIDE (THE SODIUM SALT OF N-PHENYLGLYCINEAMIDE-p-ARSONIC ACID) From the Laboratories of The Rockefeller Institute for Medical Research, New York.

This corrects the article "EXPERIMENTAL STUDIES OF THE NASOPHARYNGEAL SECRETIONS FROM INFLUENZA PATIENTS " in volume Cited by: Trypanosomiasis is a disease usually referring to African human trypanosomiasis. The synonym African sleeping sickness is often ascribed.

This infectious disease is caused by The parasites Trypanosoma brucei gambiense or Trypanosoma brucei rhodesiense cause this infectious disease, and the tsetse fly transmits the disease.[1] This disease is distinct from Chagas disease or American.

Pathogenesis of African sleeping sickness is highly complex. The clinical features displayed during HAT are often non‐specific, making it difficult to accurately diagnose the disease.

In recent years, multiple loop‐mediated isothermal amplification (LAMP) tests for the diagnosis of animal and human African trypanosomiasis have been developed Author: Jennifer Cnops, Stefan Magez.

The other drugs (suramin, melarsoprol, eflornithine, and nifurtimox) used to treat African trypanosomiasis are available in the U.S.

only from the CDC. Physicians can consult with CDC staff for advice on diagnosis and management and to obtain otherwise unavailable treatment drug. There is no test of cure for African trypanosomiasis.

Here is a thorough digest of the treatment of human trypanosomiasis with tryparsamide. The author was closely identified with this work long before the introduction of tryparsamide to the medical profession. The work with this preparation has been done in a highly scientific manner.

This corrects the article "STUDIES ON THE TREATMENT OF HUMAN TRYPANOSOMIASIS WITH TRYPARSAMIDE (THE SODIUM SALT OF N-PHENYLGLYCINEAMIDE-p-ARSONIC ACID)" in volume 34 on page 1. This corrects the article " EXPERIMENTAL STUDIES OF THE NASOPHARYNGEAL SECRETIONS FROM INFLUENZA PATIENTS " in volume 34 on page 1.

The author summarizes the results obtained in the treatment of 95 cases of sleeping sickness by tryparsamide. Most of the patients have been observed during a period of from eight to twelve months.

Owing to the limited amount of drug at disposal only very incomplete courses of 5 or 6 weekly injections could be given: the dose varied from 1 gm. to gm. per : J. Laigret. In contrast, the DFMO tolerance of T. rhodesiense is due to a faster turnover rate of the enzyme (t 1/2 = h) [ 56 ].

InDFMO was approved for the treatment of human trypanosomiasis caused by T. gambiense [ 57] and is currently the only treatment available for melarsoprol-refractory sleeping by: Seventy-two consecutive cases of trypanosomiasis in varying stages of the,disease were admitted to Tamale Hospital in and and treated by massive dose tryparsamide therapy by Author: A.F Fowler.

Pearce L () Treatment of human trypanosomiasis with tryparsamide (sodium salt of N-phenylglycineamide-p-arsonic acid). J Exp Med 34(1):1– CrossRef Google Scholar Cited by: About Trypanosomiasis: Trypanosomiasis or Chagas disease is caused by Trypanosoma cruzi, a parasite related to the African trypanosome that causes sleeping is spread by reduvid bugs and is one of the major health problems in South America.

Trans. Royal Soc. Trop. Med. and Hygiene xvi (7), TREATMENT OF AFRICAN TRYPANOSOMIASIS IN EUROPEANS. specific drugs, becomes a matter of great difficulty.

Further he has shown that in the Congo native the danger of serious visual trouble, or optic atrophy, is to be expected in 30 per cent. of the cases after tryparsamide by: 1.

Human African trypanosomiasis (HAT), or sleeping sickness, is an endemic disease affect ing 36 sub-S aharan countries. Sleeping sickness is a vector-b orne parasitic disease. Melarsoprol Resistance in African Trypanosomiasis Alan H. Fairlamb1,2 and David Horn1,3,* Arsenicals were introduced as monotherapies for the treatment of human African trypanosomiasis, or sleeping sickness, over years ago.

Toxicity has always been anissue but these drugshave proven to be both effectiveand quite durable. For treating the late disease due to T.b. gambiense tryparsamide is given intravenously at a dose of g/adult/week in doses. However, for treating advanced cases of T.b. rhodesiensis infections involving the CNS, tryparsamide is given in combination with suramin [9].

Human African trypanosomiasis or sleeping sickness is one of the most important but equally most neglected tropical infections. It is caused by a protozoan, Trypanosoma brucei, which is transmitted to humans through the bite of a tsetse fly (Glossina spp).

1 Patchy distribution of the various vector species confines the disease to some microfoci in sub-Saharan Africa (fig (fig1). 1).Cited by:   Treatment of second-stage gambiense human African trypanosomiasis relied on toxic arsenic-based derivatives for over 50 years.

The availability and subsequent use of eflornithine, initially in monotherapy and more recently in combination with nifurtimox (NECT), has drastically improved the prognosis of treated by: